Simcyp Static DDI Calculator 1.01
Free Version
Publisher Description
Metabolic drug-drug interactions (DDIs) are a major concern in drug development. Early identification of DDI potential is critical to both investigating mitigations and future clinical trial design, and therefore predictions of DDIs are important to make quantitative estimates. Current assessment of DDI can be estimated by the ratio of the area under the plasma concentration-time curve (AUC) in comparison to the control state. Predictions of DDIs can be made from combining both in vitro and in vivo data and applied in a static model, or alternatively more dynamically through application of a physiologically-based pharmacokinetic approach such as the Simcyp population-based absorption, distribution metabolism and excretion (ADME) simulator. The Simcyp Static DDI Calculator is a standalone application which has been developed to allow the quick and accurate calculation of the predicted drug-drug interaction (DDI) risk in a population representative individual. Once the substrate and inhibitor compounds have been compiled the user can rapidly calculate the DDI risk in a given population representative for the target compound. The risk of DDI can be predicted from the Rss value the observed ratio of the area under the plasma concentration time curve (AUC) following a dosing regimen of the inhibitor in comparison with the control incubation (i.e. no inhibitor). Two specific predicted AUC ratios are calculated: Method 1: This uses the Simcyp equations and assumptions to generate the predicted AUC ratio. Method 2: This uses the equations and assumptions listed in the 2012 FDA draft guidance (page 54) which is based on the published approach (Fahmi et al, 2008) to predict the AUC ratio. Once a value for the AUC has been generated the clearance of a drug can be accurately calculated, independent of the profile of the generated concentration-time curve.
Requires iOS 7.1 or later. Compatible with iPhone, iPad, and iPod touch.
About Simcyp Static DDI Calculator
Simcyp Static DDI Calculator is a free app for iOS published in the Health & Nutrition list of apps, part of Home & Hobby.
The company that develops Simcyp Static DDI Calculator is Simcyp Limited. The latest version released by its developer is 1.01. This app was rated by 2 users of our site and has an average rating of 2.3.
To install Simcyp Static DDI Calculator on your iOS device, just click the green Continue To App button above to start the installation process. The app is listed on our website since 2016-10-05 and was downloaded 33 times. We have already checked if the download link is safe, however for your own protection we recommend that you scan the downloaded app with your antivirus. Your antivirus may detect the Simcyp Static DDI Calculator as malware if the download link is broken.
How to install Simcyp Static DDI Calculator on your iOS device:
- Click on the Continue To App button on our website. This will redirect you to the App Store.
- Once the Simcyp Static DDI Calculator is shown in the iTunes listing of your iOS device, you can start its download and installation. Tap on the GET button to the right of the app to start downloading it.
- If you are not logged-in the iOS appstore app, you'll be prompted for your your Apple ID and/or password.
- After Simcyp Static DDI Calculator is downloaded, you'll see an INSTALL button to the right. Tap on it to start the actual installation of the iOS app.
- Once installation is finished you can tap on the OPEN button to start it. Its icon will also be added to your device home screen.
